Basic Information
VIS ID
TVIS10013988
Fusion event
HBV-LOC100287497 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1977
Orient
+
Integrated sequence
GCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCT| |TCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAA
Host Sequence
Chromosome
chr1
Cytoband
q42.11
Reference genome
GRCh37/hg19
Start
224201314/224013612 (Hg38)
End
224201314/224013612 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC100287497
Nearest miRNA
hsa-mir-101-1/Upstream/3812993; hsa-mir-1182/Downstream/243428;
Nearest TSS
ENST00000473358/Upstream/19350; ENST00000519894/Downstream/100475;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/20490, chr1-CpG: 46/Downstream/100594
Nearby gene
TP53BP2(-167640) ; FBXO28(+100475) ;
Upstream sequence
atggaatacagttgaattgaatggacccgaaagcaatggaaggaatggaatggaacggattggaagggaatggaatggaatgaaatggaaaagactcgaa
Downstream sequence
tggaatggaatggaatggaatggaatggaatggaatggaatggaatggaatggaatggaatggaatggactcgaatgaaatggaatggactcgaatgaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate