Basic Information
VIS ID
TVIS10013989
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
172
Orient
+
Integrated sequence
AGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACAT| |CAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCT
Host Sequence
Chromosome
chr1
Cytoband
p32.3
Reference genome
GRCh37/hg19
Start
55963448/55497775 (Hg38)
End
55963448/55497775 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA1B
Nearest miRNA
hsa-mir-12136/Upstream/272052; hsa-mir-101-1/Downstream/4235452;
Nearest TSS
ENST00000473358/Upstream/136367; ENST00000422374/Downstream/83262;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/281740, chr1-CpG: 47/Downstream/979780
Nearby gene
MIR4422(-272052) ; PLPP3(+996971) ;
Upstream sequence
CTCAGCCTCTCCCAAAAGAATAAAAACAAAAGCCTGACCAGCTACTGCATCCCTACTATGCCTCCAGTTCTTTCTAAAGCCCAAGGATTAATTGTAAAGT
Downstream sequence
TCACTGTTACTATTAGCCACATATGTAATAGTGGGGAAAATGGAGAGTAAAGAAGAGGAAACTGCAGTAAAATATACAAATACTTGACACTATCAGGAAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate