VISDB Viral Integration Site DataBase

VIS ID

TVIS10013990

Fusion event

HBV-ERRFI1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|Polymerase|

Start

2355

Orient

-

Integrated sequence

TTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGA| |CGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGT

Chromosome

chr1

Cytoband

p36.23

Reference genome

Start

End

8084038/8023978 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-200c-3p ; hsa-mir-193b-3p ; hsa-mir-429 ; hsa-mir-200b-3p ; hsa-mir-423-5p ; hsa-mir-378a-3p ; hsa-mir-18a-5p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-148a-3p ; hsa-mir-6083 ; hsa-mir-675-3p ; hsa-mir-448 ; hsa-mir-331-5p ; hsa-mir-125b-2-3p ; hsa-mir-380-3p ; hsa-mir-411-3p ; hsa-mir-379-3p ; hsa-mir-4495 ; hsa-mir-586 ; hsa-mir-4678 ; hsa-mir-140-3p ; hsa-mir-2355-5p ; hsa-mir-3914 ; hsa-mir-3922-5p ; hsa-mir-4427 ; hsa-mir-4457 ; hsa-mir-4724-5p ; hsa-mir-4731-3p ; hsa-mir-4753-5p ; hsa-mir-4801 ; hsa-mir-5585-3p ; hsa-mir-634 ; hsa-mir-6840-3p

Nearest miRNA

hsa-mir-12136/Upstream/1594082; hsa-mir-101-1/Downstream/842524;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/61812, chr1-CpG: 155/Downstream/1516

Nearest cancer related gene

ERRFI1(TSG, No orient, 0)

Upstream sequence

GTTTATGTAGCGAGTTCTTTATTAGCTTTTGTATAGCCAGACACCCGCAAAGGATGCTAAATGTATCCAAATGGATCCAGATGATGAGGTACCAATTCAA

Downstream sequence

ATTTATTTAGATCAAGAGCAGAGTTGTTTCTCTGGCAGAGGGAGCCTATGCCATTCCAATTCCTGGAGTTACCCCTGACACCTCCTTTCCTTCCTCTGCT