Basic Information
VIS ID
TVIS10013991
Fusion event
HBV-RNU6-53P integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
3206
Orient
-
Integrated sequence
CAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGCCATGCAGTGG| |
Host Sequence
Chromosome
chr10
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
110954436/109194678 (Hg38)
End
110954436/109194678 (Hg38)
Orient
-
Location type
ncRNA_intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
RNU6-53P
Nearest miRNA
hsa-mir-107/Upstream/4926273; hsa-mir-202/Downstream/1703412;
Nearest TSS
ENST00000439456/Upstream/484160; ENST00000459738/Downstream/676354;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/282110, chr10-CpG: 52/Downstream/262168
Upstream sequence
ccatgtgttctcattgttcaattcctacatatgagtgagaacatgcggtgtttggttttctgttcctgtgttggtttgctgagaatgatggtttccagct
Downstream sequence
tcatccatgtccttacaaaggacataaactcatcctttttatggctgcatagtattccatggtatatatgtgccacattttctttatccaatctatcata
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate