MMP26 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10013998
Fusion event
HBV-MMP26 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1606
Orient
+
Integrated sequence
CGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGT| |CGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCAT
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh37/hg19
Start
5011291/4990061 (Hg38)
End
5011291/4990061 (Hg38)
Orient
-
Location type
Intronic
Target gene
MMP26
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-125b-5p
Nearest miRNA
hsa-mir-210/Upstream/1133920; hsa-let-7a-2/Downstream/2244705;
Nearest TSS
ENST00000527297/Upstream/1867; ENST00000321543/Downstream/4790;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/381761, chr11-CpG: 32/Downstream/1244477
Upstream sequence
CTGCTTTCATTGGCAGCCCGCTCAAAGCCCAAAATCTCCCTCAGAGAAGGTAATACTACCAGATCCTTTTCTAGCTTCCTCTAACCATCTCTTTAGAAAG
Downstream sequence
TAGAGAGCATAACCACTATCCTTTCCCTTTGTTAAATCTTTTCTTTTTAATTTTAATGCGTGAGTGTGTGGATGGTTCTAAGGTACAATTTTGAAAACTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate