VISDB Viral Integration Site DataBase

VIS ID

TVIS10014002

Fusion event

HBV-CACNA1C integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

439

Orient

-

Integrated sequence

CCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGT| |TGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGC

Chromosome

chr12

Cytoband

p13.33

Reference genome

Start

End

2250290/2141124 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-133a-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-4780 ; hsa-mir-6780b-3p ; hsa-mir-3938 ; hsa-mir-6791-5p ; hsa-mir-6778-5p ; hsa-mir-450a-2-3p ; hsa-mir-6857-5p ; hsa-mir-6763-5p ; hsa-mir-3150a-3p ; hsa-mir-6810-5p ; hsa-mir-2110 ; hsa-mir-3147 ; hsa-mir-4425 ; hsa-mir-185-3p ; hsa-mir-4283 ; hsa-mir-4489 ; hsa-mir-6825-5p ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-3175 ; hsa-mir-5001-5p ; hsa-mir-762 ; hsa-mir-4498 ; hsa-mir-4492 ; hsa-mir-7106-5p ; hsa-mir-920 ; hsa-mir-6726-5p ; hsa-mir-5591-5p ; hsa-mir-4300 ; hsa-mir-5787 ; hsa-mir-4505 ; hsa-mir-4731-5p ; hsa-mir-6754-5p ; hsa-mir-4487 ; hsa-mir-4441 ; hsa-mir-4270 ; hsa-mir-29a-3p ; hsa-mir-208a-3p ; hsa-mir-208b-3p ; hsa-mir-103a-3p

Nearest miRNA

hsa-mir-3649/Upstream/480744; hsa-let-7i/Downstream/4822575;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/25645, chr12-CpG: 42/Downstream/88872

Upstream sequence

aggtggtgacaagatgggctggctctgggcagacctggggaggaggctgcgggcaggggacagcagggccaggaccccgaggtgagcagggcccactgtg

Downstream sequence

gctgctgctcaggaggggagatgaaggaggatgtgagtggggttggaggggcagacaggggctgaattatgtggGTCAGCATGAGGAGTTTGTTGTGAGT