Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10014012
Fusion event
HBV-ZNF835 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|
Start
2290
Orient
+
Integrated sequence
TTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTC| |CAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCC
Host Sequence
Chromosome
chr19
Cytoband
q13.43
Reference genome
Start
End
57181287/56669919 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
hsa-mir-1273a ; hsa-mir-1273g-3p ; hsa-mir-4486 ; hsa-mir-4537 ; hsa-mir-455-3p ; hsa-mir-4649-5p ; hsa-mir-4711-5p ; hsa-mir-4793-3p ; hsa-mir-508-5p ; hsa-mir-5186 ; hsa-mir-6499-3p ; hsa-mir-6512-3p ; hsa-mir-6516-5p ; hsa-mir-661 ; hsa-mir-6720-5p ; hsa-mir-6729-5p ; hsa-mir-6849-3p ; hsa-mir-6890-3p ; hsa-mir-7112-3p ; hsa-mir-766-3p ; hsa-mir-7703 ; hsa-mir-939-3p ; hsa-mir-377-5p ; hsa-mir-6086
Nearest miRNA
hsa-let-7e/Upstream/1281677; hsa-mir-10394/Downstream/1664769;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/4880, chr19-CpG: 46/Downstream/1600
Upstream sequence
GGCCTATCAGGAGTCCTCCATTAGCATAAATGTACTTGGGGGCCTACCAGGAGTCCTCCATTAGCATAAATGTACTTGGGGGCCTATCAGGAGTCCTCCA
Downstream sequence
TTAGCATAAATGTACTTGGGGGCCTATCAGGAGTCCTCCATTAGCATAAATGTACTTGGGGGCCTATCAGGAGTCCTCCATTAGCATAAATGTACTTGGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.