Basic Information
VIS ID
TVIS10014039
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
82
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAA| |CAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCT
Host Sequence
Chromosome
chr2
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
92281252/92093226 (Hg38)
End
92281252/92093226 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-1285-2/Upstream/3280772; hsa-mir-10b/Downstream/4705052;
Nearest TSS
ENST00000437798/Upstream/275455; ENST00000561882/Downstream/2495296;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/18189, chr2-CpG: 119/Downstream/2179607
Nearby gene
ACTR3BP2(-150756) ;
Upstream sequence
atttgcatgtgaatatttgtacaactttgaggattttgtcggaaacctggaaatcttcctatgaaatcgagacaagcattctcaggaatctctttgggat
Downstream sequence
gttagcattcgagtcacagagttgaacattccctttcatagagcaggtttgaaacactctttttgtagtgtctggaagtggacatttggattgctttcag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate