ITSN1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10014044
Fusion event
HBV-ITSN1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
731
Orient
-
Integrated sequence
GAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCT| |TTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATAC
Host Sequence
Chromosome
chr21
Cytoband
q22.11
Reference genome
GRCh37/hg19
Start
35254544/33882240 (Hg38)
End
35254544/33882240 (Hg38)
Orient
+
Location type
Intronic
Target gene
ITSN1
miRNAs that regulate target gene
hsa-mir-296-3p ; hsa-mir-194-5p
Nearest miRNA
hsa-let-7c/Upstream/331512; hsa-mir-3197/Downstream/1838475;
Nearest TSS
ENST00000624081/Upstream/6880; ENST00000610236/Downstream/25172;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/238862, chr21-CpG: 36/Downstream/33259
Upstream sequence
TCCGAGTCTGCTGGGGCCTGGCCTCTGATTCTGATGGAGCCCATGCTTTCAGATGCGGAGAAACAAAAATGCTACACTTTGGGTTTTGTTTTCCTTTCTC
Downstream sequence
AGCAACTTGTGTTCAATTCAGTGACCAATTGCTTGGGGCCGCGCAAATTTCTGCACAGTGGGAAGCTCTACAAGGCCAAGAGCAACAAGGAGCTGTATGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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