PCBP3 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10014045
Fusion event
HBV-PCBP3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2083
Orient
+
Integrated sequence
CGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTT| |GCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGG
Host Sequence
Chromosome
chr21
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
47191315/45771401 (Hg38)
End
47191315/45771401 (Hg38)
Orient
+
Location type
Intronic
Target gene
PCBP3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p
Nearest miRNA
hsa-let-7c/Upstream/293075;
Nearest TSS
ENST00000624081/Upstream/7643; ENST00000481302/Downstream/65018;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/24389, chr21-CpG: 37/Downstream/95697
Nearby gene
SLC19A1(-228930) ; LOC100129027(+56440) ;
Upstream sequence
TTCATGATGAGGTCACTAAAGTTCTGTCTCAAGCACATGGTGGGCGTTCAGTaaagacttagagatttcggttgaccagacatttagcattaattagcag
Downstream sequence
tttagtgtggtgggtgactgaaaagtaaatgtaagctttgagcattTTCAGAGCATCATTTTGTCTaaaattaatcagtatatttcaccgtcttaacaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate