Basic Information
VIS ID
TVIS10014049
Fusion event
HBV-LOC285500 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1822
Orient
+
Integrated sequence
GTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAAC| |TTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAA
Host Sequence
Chromosome
chr4
Cytoband
q34.3
Reference genome
GRCh37/hg19
Start
178387590/177466436 (Hg38)
End
178387590/177466436 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC285500
Nearest miRNA
hsa-mir-12113/Upstream/3042572; hsa-mir-1305/Downstream/4702857;
Nearest TSS
ENST00000502981/Upstream/21457; ENST00000507870/Downstream/224632;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/23882, chr4-CpG: 160/Downstream/2591449
Nearby gene
AGA(-23933) ; LINC01098(+262321) ;
Upstream sequence
agattctggtaagttgtgtctttgttctcgttggtttcaaagaacatctttatttctgccttcatttcgttatgtacccagtagtcattcaggagcaggt
Downstream sequence
tgggactacaggtatgcgccattattcccagctattttttattatcttttttgtagagatggcgtttcaccattttgcccaggctACTTCTCTCTCTCTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate