Basic Information
VIS ID
TVIS10014055
Fusion event
HBV-ADGRL3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2492
Orient
+
Integrated sequence
GCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGC| |TTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTT
Host Sequence
Chromosome
chr4
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
62445480/61579762 (Hg38)
End
62445480/61579762 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADGRL3
miRNAs that regulate target gene
hsa-mir-20a-5p
Nearest miRNA
hsa-mir-12113/Upstream/657078; hsa-mir-1243/Downstream/4697062;
Nearest TSS
ENST00000502981/Upstream/82468; ENST00000509089/Downstream/7606;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/376679, chr4-CpG: 60/Downstream/1769367
Upstream sequence
tgctcctgaatgactactgggtacataacgaaatgaaggcagaaataaagatgttctttgaaaccaacgagaacaaagacaccacataccagaatctctg
Downstream sequence
TTTAATTGTCACTTTGTTACACTTAGTTAAATGCTAAAATGCCATTTCAATTATATGTATTCTTTTTTGAAATAGAATTGTTAGAATTCAGTGTATTAGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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