VISDB Viral Integration Site DataBase

VIS ID

TVIS10014060

Fusion event

HBV-TERT integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

986

Orient

+

Integrated sequence

TGTCATTGGATGTTATGGGTCCTTGCCACAAGAACACATCATACAAAAAATCAAAGAATGTTTTAGAAAACTTCCTATTAACAGGCCTATTGATTGGAAA| |GTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTCAATCTAAGC

Chromosome

chr5

Cytoband

p15.33

Reference genome

Start

End

1296139/1296024 (Hg38)

Orient

+

Location type

upstream

Target gene

miRNAs that regulate target gene

hsa-mir-138-5p ; hsa-mir-498 ; hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-512-5p ; hsa-mir-1207-5p ; hsa-mir-1266-5p ; hsa-mir-1182 ; hsa-mir-181a-5p ; hsa-mir-6776-3p ; hsa-mir-197-3p ; hsa-mir-6740-3p ; hsa-mir-6760-3p ; hsa-mir-532-5p ; hsa-mir-3064-5p ; hsa-mir-422a ; hsa-mir-346 ; hsa-mir-1226-3p ; hsa-mir-1255a ; hsa-mir-1255b-5p ; hsa-mir-143-3p ; hsa-mir-3161 ; hsa-mir-3605-5p ; hsa-mir-3620-3p ; hsa-mir-3682-3p ; hsa-mir-4323 ; hsa-mir-4712-3p ; hsa-mir-4733-3p ; hsa-mir-4758-3p ; hsa-mir-4770 ; hsa-mir-6088 ; hsa-mir-7112-3p

Nearest miRNA

hsa-mir-4635/Upstream/233050; hsa-mir-10397/Downstream/13286;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/169, chr5-CpG: 18/Downstream/38938

Nearest cancer related gene

TERT(OG, No orient, 0)

Upstream sequence

GTTTGGAAAATTTGTTCCAACAAAAGTTAAGTTGTAGCTTACACTGGTTCTCTGCAGAGAAGCCAACATAGAAAACACAATTTTAAAAGAGGGAAGAGAA

Downstream sequence

GCAGTAGAAGCCACACGGCCACTGGTCCCCTCCAGACCTGGGGCCCCGGCACAACCGCAGGACAGCTGAGGACTTCCCAGGAATCCAGACTCCGGGTTGC