Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10014061
Fusion event
HBV-SLC1A3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
722
Orient
-
Integrated sequence
GGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCAC| |TGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTT
Host Sequence
Chromosome
chr5
Cytoband
p13.2
Reference genome
Start
End
36609066/36608964 (Hg38)
Orient
-
Location type
UTR3
Fragile sites / regions
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-10397/Upstream/460976; hsa-mir-103a-1/Downstream/1948538;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/366402, chr5-CpG: 45/Downstream/81141
Upstream sequence
TTTGGAAAATTTGTTCCAACAAAAGTTAAGTTGTAGCTTACACTGGTTCTCTGCAGAGAAGCCAACATAGAAAACACAATTTTAAAAGAGGGAAGAGAAG
Downstream sequence
ACTTAAAACTAATTTATACAATTAGTACACCTAAAATGACATGTTGGTTCCAAATAGTAATTATATTCTAACTGGTGCTGACTTGAAGCTGAGTATCAAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.