Basic Information
VIS ID
TVIS10014070
Fusion event
HBV-LOC100996643 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
82
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAA| |CAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCT
Host Sequence
Chromosome
chr9
Cytoband
q13
Reference genome
GRCh37/hg19
Start
67320759/63365787 (Hg38)
End
67320759/63365787 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA9F
Target gene
LOC100996643
Nearest miRNA
hsa-mir-101-2/Upstream/22131952; hsa-let-7a-1/Downstream/7444188;
Nearest TSS
ENST00000422679/Upstream/467681; ENST00000431077/Downstream/363090;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/449742, chr9-CpG: 299/Downstream/83083
Nearby gene
AQP7P1(-31267) ; FAM27B(+472170) ;
Upstream sequence
gttaccaaaaattcagaaaataatgagtgttggtgaagatgtggagaaattggagcccttgcacactcttgataggattgtaaaatggtgcagctgctat
Downstream sequence
gtttgcattcaagtcacagagttgaacattccctttcacagagcaggtttgaaacactctttttgtagtatctggaagtgcacatttggagcgcattcag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate