Basic Information
VIS ID
TVIS10014072
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1128
Orient
-
Integrated sequence
TTTACACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTA| |AACAATACCTGAACCTTTACCCCGTTGCCCGGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCA
Host Sequence
Chromosome
chrX
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
34887192/34869075 (Hg38)
End
34887192/34869075 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-23c/Upstream/2227516; hsa-let-7f-2/Downstream/3154820;
Nearest TSS
ENST00000429181/Upstream/211787; ENST00000329357/Downstream/73721;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/211465, chrX-CpG: 23/Downstream/74238
Nearby gene
TMEM47(-211787) ; FAM47B(+73721) ;
Upstream sequence
cagcaccaagtggatggtgctaaaccattcatgagaactccactctatgatccaaccacctcccatcaggccccacctccaacattggggattataattg
Downstream sequence
ctacaaagagacctagactcccacacaaaaatagtgaatgaattcaacactcccctgacactattagataaatcatcaaggcagaaaacaaacaaagata
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate