Basic Information
VIS ID
TVIS10014074
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
778
Orient
-
Integrated sequence
TTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCA| |TCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACAAAGAGATGGGGTTACTCTCTAAATTTT
Host Sequence
Chromosome
chr1
Cytoband
p36.33
Reference genome
GRCh37/hg19
Start
10377/10377 (Hg38)
End
10377/10377 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1A
Nearest miRNA
hsa-mir-101-1/Downstream/6992;
Nearest TSS
ENST00000473358/Downstream/19177;
Nearest CpG islands
None/Target, None/Upstream, chr1-CpG: 111/Downstream/18358
Nearby gene
DDX11L1(+1497) ;
Upstream sequence
ctaaccctaaccccaaccccaaccccaaccccaaccccaaccccaaccctaacccctaaccctaaccctaaccctaccctaaccctaaccctaaccctaa
Downstream sequence
ccctaaccctaacccctaacccctaaccctaaccctaaccctaaccctaaccctaaccctaacccctaaccctaaccctaaccctaaccctcgcggtacc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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