Basic Information
VIS ID
TVIS10014077
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1839
Orient
+
Integrated sequence
AGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTA| |ATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTG
Host Sequence
Chromosome
chr1
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
192820527/192851397 (Hg38)
End
192820527/192851397 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1K
Target gene
LOC105371667 ; LOC105371668
Nearest miRNA
hsa-mir-101-1/Upstream/135007; hsa-mir-1182/Downstream/285106;
Nearest TSS
ENST00000473358/Upstream/42254; ENST00000469214/Downstream/74318;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/42329, chr1-CpG: 94/Downstream/207694
Nearby gene
RGS2(-39120) ; UCHL5(+160969) ;
Upstream sequence
CTGCAGAAACTCATTATTTTCTGAGAGCAAAAATGGCCATAACTCTGCCTCAGCCTGGCTAGAGACATTTCTGCTTGTTCCTCCCTCTCAACAGGGTCAC
Downstream sequence
TGCTCAGATACTTCAGGAAAGAACAGAAAGAAGATAGCTTTCTTTATTCTGAGAAAAAGGGCAAGCAGGCAGATTCCTTCCCCACCATTTGTGGGAGAAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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