VISDB Viral Integration Site DataBase

VIS ID

TVIS10014078

Fusion event

HBV-RYR2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1771

Orient

+

Integrated sequence

ACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTT| |GTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGC

Chromosome

chr1

Cytoband

q43

Reference genome

Start

End

237766552/237603252 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-25-3p ; hsa-mir-17-5p ; hsa-let-7c-5p

Nearest miRNA

hsa-mir-101-1/Upstream/132061; hsa-mir-3123/Downstream/3529020;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/559908, chr1-CpG: 22/Downstream/180635

Upstream sequence

tagtgacgttcatgaatggatgaacgagattcccactgtccctacctactatccagcgaaaccacagccaagggaacgggcttggtggaatccgcgggga

Downstream sequence

aagaagaccctgttgagcttgactctagtctggcacggtgaagagccatgagaagtgtagaataagtgggaggcccctggtgcccccctgtcccagcaag