VISDB Viral Integration Site DataBase

VIS ID

TVIS10014091

Fusion event

HBV-YAP1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|

Start

1895

Orient

+

Integrated sequence

TTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCT| |TTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTA

Chromosome

chr11

Cytoband

q22.1

Reference genome

Start

End

101994836/102124105 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-let-7b-5p ; hsa-mir-630 ; hsa-mir-375 ; hsa-mir-200a-3p ; hsa-mir-26b-5p ; hsa-mir-141-3p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-559 ; hsa-mir-548b-5p ; hsa-mir-548a-5p ; hsa-mir-548c-5p ; hsa-mir-548d-5p ; hsa-mir-1468-3p ; hsa-mir-877-5p ; hsa-mir-548j-5p ; hsa-mir-548k ; hsa-mir-548l ; hsa-mir-548h-5p ; hsa-mir-548p ; hsa-mir-548i ; hsa-mir-3121-3p ; hsa-mir-3125 ; hsa-mir-3159 ; hsa-mir-548w ; hsa-mir-3916 ; hsa-mir-548y ; hsa-mir-548o-5p ; hsa-mir-548ab ; hsa-mir-548ad-5p ; hsa-mir-548ae-5p ; hsa-mir-548ak ; hsa-mir-548am-5p ; hsa-mir-548ap-5p ; hsa-mir-548aq-5p ; hsa-mir-548ar-5p ; hsa-mir-548as-5p ; hsa-mir-548au-5p ; hsa-mir-548av-5p ; hsa-mir-548ay-5p ; hsa-mir-6859-5p ; hsa-mir-8054 ; hsa-mir-548bb-5p ; hsa-mir-506-3p ; hsa-mir-4639-5p ; hsa-mir-6844 ; hsa-mir-138-2-3p ; hsa-mir-4272 ; hsa-mir-4729 ; hsa-mir-10a-3p ; hsa-mir-509-3p ; hsa-mir-27a-3p ; hsa-mir-195-5p ; hsa-mir-424-3p ; hsa-mir-199a-3p ; hsa-mir-138-5p

Nearest miRNA

hsa-mir-10392/Upstream/604200; hsa-let-7a-2/Downstream/1725801;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/12506, chr11-CpG: 19/Downstream/144588

Nearest cancer related gene

YAP1(OG, No orient, 0)

Upstream sequence

caggggtgtgatctcggctcatcgcaatctctggctcccgggttcaagcgattctcctgccttagcctcctgagtagccgggattacaggcgtgtgccac

Downstream sequence

catgccccagctaatttttgtatttttagtagaggcggggtttcaccatgttggccaggttggtctcgaactcctgacctcaagtgatctgcctgcctca