Basic Information
VIS ID
TVIS10014095
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2073
Orient
+
Integrated sequence
TCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAA| |GCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACA
Host Sequence
Chromosome
chr11
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
66753675/66986204 (Hg38)
End
66753675/66986204 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA11H
Nearest miRNA
hsa-mir-10392/Upstream/51698; hsa-let-7a-2/Downstream/59439;
Nearest TSS
ENST00000527297/Upstream/10927; ENST00000531392/Downstream/20574;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/27302, chr11-CpG: 77/Downstream/37119
Nearby gene
C11orf86(-9196) ; SYT12(+36515) ;
Upstream sequence
GGATCTGGGAAAGTGGGTCCAGCCCCAGACCAGATGGCCACCCTGGGGCCTCCCAGGAGGTGGGCTGTCCTTTAATGACCTGCATGGTCGTGGGTTTGGG
Downstream sequence
AGGAAGGAGCTTTCTCCCGGCCCCCTACTCCCACTGTGGCTGCCAAAGAACCCTCCCTGTCCCACCCCAGCCAGGCCATGTCTCCCTTCTCTGAGCTTCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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