Basic Information
VIS ID
TVIS10014096
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
209
Orient
-
Integrated sequence
CTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGG| |GTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAA
Host Sequence
Chromosome
chr11
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
69561490/69746722 (Hg38)
End
69561490/69746722 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA11H ; FRA11A
Nearest miRNA
hsa-mir-10392/Upstream/663464; hsa-let-7a-2/Downstream/537233;
Nearest TSS
ENST00000527297/Upstream/42080; ENST00000534086/Downstream/28442;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/41561, chr11-CpG: 196/Downstream/27336
Nearby gene
FGF19(-42384) ; FGF4(+26307) ;
Nearest cancer related gene
FGF4(OG, +26307) ;
Upstream sequence
TGGGGCCAAATGCCCTTGGCCGCCTCTTTCCTTCTCTTTTATGGGTCTCCAGTCCCGCCTGGGACGGAGAGGGTTACTGGAGACACGCTTTGTACTTCAA
Downstream sequence
TAGGCACTTTCATCTGCAGCCTTTGGAGGGCTTTGCAAACATGGCTTAATGAAGGGTCCCAGCACCCCAGCCTCCTAAGCACCGTTTTGAGCTGGATGCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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