Basic Information
VIS ID
TVIS10014100
Fusion event
HBV-ME3-DT integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1809
Orient
-
Integrated sequence
TCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACC| |AGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACA
Host Sequence
Chromosome
chr11
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
86454443/86743401 (Hg38)
End
86454443/86743401 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11F
Target gene
ME3-DT
Nearest miRNA
hsa-mir-10392/Upstream/465003; hsa-let-7a-2/Downstream/1433101;
Nearest TSS
ENST00000527297/Upstream/16046; ENST00000527521/Downstream/47658;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/70857, chr11-CpG: 92/Downstream/56741
Nearby gene
ME3(-70765) ; PRSS23(+57048) ;
Upstream sequence
TCTGACAGCCCGTTGCCACAGAGCACCACCCACAGAGCAGAGGATCCACACTCAGTATTACATAGCATCAGCAGAAACAGAGGCTGACCCCCTTGGTGAG
Downstream sequence
GCCACTTCAGTTTCCTTGTTCTTGGGCCACCCATGAGCACCTCTGACAGTTTAAAAGATACTCTTACAAGCCAAAGGAGAGAAGTATAGCCCAGGATTCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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