Basic Information
VIS ID
TVIS10014101
Fusion event
HBV-C11orf97 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
363
Orient
-
Integrated sequence
GACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGT| |CCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTA
Host Sequence
Chromosome
chr11
Cytoband
q21
Reference genome
GRCh37/hg19
Start
94255062/94521896 (Hg38)
End
94255062/94521896 (Hg38)
Orient
-
Location type
Intronic
Target gene
C11orf97
Nearest miRNA
hsa-mir-10392/Upstream/55316; hsa-let-7a-2/Downstream/1819542;
Nearest TSS
ENST00000527297/Upstream/9464; ENST00000358752/Downstream/21944;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/9171, chr11-CpG: 193/Downstream/21832
Upstream sequence
attcagatctgacccccaatcccattggctttctactcactatggtgtctctggtgacacgttatggctaaatgcagtggatactgttctgcctctaggt
Downstream sequence
ggcttgagctttctgcaacatttcacatagtcgatggctctctccttcaaccttgttcctttctcaaattccatgatacttaactgtcctggttctcgct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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