Basic Information
VIS ID
TVIS10014104
Fusion event
HBV-LOC283335 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1790
Orient
-
Integrated sequence
ACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGC| |ATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGG
Host Sequence
Chromosome
chr12
Cytoband
q13.13
Reference genome
GRCh37/hg19
Start
53440547/53046763 (Hg38)
End
53440547/53046763 (Hg38)
Orient
-
Location type
ncRNA_intronic
Fragile sites / regions
FRA12A
Target gene
LOC283335
Nearest miRNA
hsa-mir-1244-3/Upstream/147779; hsa-let-7i/Downstream/10181;
Nearest TSS
ENST00000382841/Upstream/702; ENST00000551302/Downstream/196;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/39651, chr12-CpG: 106/Downstream/32
Upstream sequence
ACCAGGTGTCTTCACCTGATTCAGGCGCCCGCCTGGGTAGGGGACGCTAGCACCACCAGGCTAAGCCACGGGTGGTCCTCTCAGGTCAGGCCCAAGCCCA
Downstream sequence
GGCACACTCCTGTGGGGAGGGTAAGAGGCTGACGCTGCGCGGCAGTTCCCTGTCCCCTTGTTCCTAGTCCCTTCTAGACCTACGCCCACCGTTTCTTCTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate