Basic Information
VIS ID
TVIS10014112
Fusion event
HBV-chr13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
54
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTAT| |TTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGA
Host Sequence
Chromosome
chr13
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
85316572/84742437 (Hg38)
End
85316572/84742437 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1297/Upstream/7044321; hsa-mir-1267/Downstream/2876228;
Nearest TSS
ENST00000623511/Upstream/180073; ENST00000424926/Downstream/336483;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/862675, chr13-CpG: 121/Downstream/2928877
Nearby gene
LINC00333(-135669) ; LINC00351(+621166) ;
Upstream sequence
TCATTATTGTACAAAAGAGAAATTGTTCATCAGTGGTTAACTTTACACATAACCTTCAGATTCATATGGTGATCATAACACAACTAGTGGACTAATTATA
Downstream sequence
ATAATTCAGAAATAGATATCCTCATATTTGCTTAGAGTTAGAAAAAATAGAGTACCTGGTGTTCTGTTTTGAAGAGAGAGTAATGAAAATAGTTGAATTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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