Basic Information
VIS ID
TVIS10014114
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2246
Orient
+
Integrated sequence
GAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGT| |TATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTT
Host Sequence
Chromosome
chr14
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
24234861/23765652 (Hg38)
End
24234861/23765652 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-208a/Upstream/347589; hsa-mir-1185-1/Downstream/377837;
Nearest TSS
ENST00000550708/Upstream/122607; ENST00000543741/Downstream/168916;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/187934, chr14-CpG: 32/Downstream/187909
Nearby gene
DHRS2(-120013) ; DHRS4-AS1(+173079) ;
Upstream sequence
atgctgttaaaattaaagcaaaaacaaacctcaaatttatggtgaagcttgtgtggaagaatgacaatttatgaaaactttatagggaaaatgcctcaag
Downstream sequence
gaaattagcagtttacaaatggataacctgttttaagaagaggcaagaggatgttgaaaatgaaggccacagtggcagaccatccacatcaattagtgag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate