Basic Information
VIS ID
TVIS10014115
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2966
Orient
-
Integrated sequence
CACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGAC| |ACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCA
Host Sequence
Chromosome
chr14
Cytoband
q12
Reference genome
GRCh37/hg19
Start
24818816/24349610 (Hg38)
End
24818816/24349610 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-208a/Upstream/206045; hsa-mir-1185-1/Downstream/2559032;
Nearest TSS
ENST00000550708/Upstream/9565; ENST00000554903/Downstream/16063;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/9824, chr14-CpG: 39/Downstream/16994
Nearby gene
RIPK3(-9574) ; NFATC4(+17329) ;
Upstream sequence
aagctgtggaatggtcttgagctacattgcaacatgattagatctgtgacttaggaggctcaagccagtggctacatggtgcatgaaatgagatggggag
Downstream sequence
aactggaggcagggaaaactgcaggccacagttagagcaattcaagtgagaggtgatgaggacctgaaccaagttaatgcctgcagggatcgagaggaag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate