Basic Information
VIS ID
TVIS10014116
Fusion event
HBV-HERC2P3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1054
Orient
+
Integrated sequence
AACTTCCTATTAACAGGCCTATTGATTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATGTGGTTATCCTGCGTT| |GATGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTT
Host Sequence
Chromosome
chr15
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
20627121/20421868 (Hg38)
End
20627121/20421868 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
HERC2P3
Nearest miRNA
hsa-mir-10393/Downstream/410927;
Nearest TSS
ENST00000557528/Upstream/69507; ENST00000560839/Downstream/119932;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/62912, chr15-CpG: 58/Downstream/84243
Upstream sequence
tagttgtgtgcagtatctattgttcccatgttaattttcatgtgtgcttaatgtttagctccaacatatacatgggaatatgtggagttttgctttttgt
Downstream sequence
tcctgtattaatttgcttaggactatggcctccaggtccatctatgttgctgcatgggacatgatttcattatactttatgctgcatggtattccatgat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate