Basic Information
VIS ID
TVIS10014117
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
334
Orient
-
Integrated sequence
ACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATC| |ACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTT
Host Sequence
Chromosome
chr15
Cytoband
q14
Reference genome
GRCh37/hg19
Start
36189938/35897737 (Hg38)
End
36189938/35897737 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1233-1/Upstream/525373; hsa-mir-10393/Downstream/29119;
Nearest TSS
ENST00000557528/Upstream/41260; ENST00000560056/Downstream/77032;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/351423, chr15-CpG: 35/Downstream/681521
Nearby gene
DPH6-DT(-38736) ; MIR4510(+29119) ;
Upstream sequence
tttatgttcctttttttccctctttttatgtgtttgttttttatcttattttggatcaattaatatttattatttcatttcaacttcatattggtttatt
Downstream sequence
agcagtacctcttttttagttGGTTGCTCCTCTTTTTACATATTAAATAAAGTAAGCCTTAAAATGGTTAACCACTTGCCGAAAAATTGcataataatta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate