Basic Information
VIS ID
TVIS10014118
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1767
Orient
-
Integrated sequence
TTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGT| |CTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTC
Host Sequence
Chromosome
chr15
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
73602563/73310222 (Hg38)
End
73602563/73310222 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10393/Upstream/10243; hsa-mir-11181/Downstream/1101135;
Nearest TSS
ENST00000557528/Upstream/11923; ENST00000558742/Downstream/25038;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/257194, chr15-CpG: 29/Downstream/8610
Nearby gene
NEO1(-5016) ; HCN4(+9637) ;
Upstream sequence
TGACCCAAGTGGTAGATGAAAAAAGAGGTTGGGGTTTCCTCAGGGAAAAGCCTAATACTAAGAACCAGAGGGAAGCCTGACTGACGCTTATCAAAAAATA
Downstream sequence
AGTAAATGAGTGATCATCATCTTCCCTGAGAAtttgttgagaattttgtgtctatattcataagagatattggtctgtagttttttttgaaggggggagt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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