VISDB Viral Integration Site DataBase

VIS ID

TVIS10014127

Fusion event

HBV-NPEPPS integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2117

Orient

-

Integrated sequence

GGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGT| |GGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATT

Chromosome

chr17

Cytoband

q21.32

Reference genome

Start

End

45641095/47563729 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-122-5p ; hsa-mir-484 ; hsa-mir-423-3p ; hsa-mir-320a ; hsa-mir-27b-3p ; hsa-mir-93-5p ; hsa-mir-27a-3p ; hsa-mir-491-3p ; hsa-mir-659-3p ; hsa-mir-873-5p ; hsa-mir-1277-5p ; hsa-mir-3942-3p ; hsa-mir-4424 ; hsa-mir-5100 ; hsa-mir-218-1-3p ; hsa-mir-4722-5p ; hsa-mir-1286 ; hsa-mir-3189-3p ; hsa-mir-10b-3p ; hsa-mir-141-5p ; hsa-mir-500a-5p ; hsa-mir-500b-5p ; hsa-mir-362-5p ; hsa-mir-212-5p ; hsa-mir-6807-5p ; hsa-mir-6862-3p ; hsa-mir-516a-5p ; hsa-mir-4267 ; hsa-mir-500b-3p ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-9500 ; hsa-mir-6822-5p ; hsa-mir-6750-5p ; hsa-mir-5584-5p ; hsa-mir-548m

Nearest miRNA

hsa-mir-1180/Upstream/590629; hsa-mir-10226/Downstream/469153;

Nearest TSS

Nearest CpG islands

None/Target, chr17-CpG: 26/Upstream/32114, chr17-CpG: 137/Downstream/85578

Upstream sequence

gcacgatctcggctcgctgcaagctccgcctcccgagttcacgccattttcctgcctcagcctcctgagtagctgggactataggcacgtgccaccacac

Downstream sequence

ccagctaattttttgtatttttagtagagacggggtttcaccatgttggccaggatggtctcgatctcttgacctcgtgatccgccctccttggcctcca