Basic Information
VIS ID
TVIS10014128
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1594
Orient
+
Integrated sequence
TTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTC| |ACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCG
Host Sequence
Chromosome
chr18
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
38779745/41199781 (Hg38)
End
38779745/41199781 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1-2/Upstream/1523002; hsa-mir-122/Downstream/3770301;
Nearest TSS
ENST00000575820/Upstream/1133495; ENST00000590220/Downstream/281287;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/1357916, chr18-CpG: 180/Downstream/3479237
Nearby gene
MIR924HG(-1447786) ; KC6(+280491) ;
Upstream sequence
ACAAAAATACATATTTCATAAGTTACTCAAATAATGAAGAATTGAAAAAGTCTTATCTCACTTTCTTTAGGATCAAGATTATGTTCTTAGTTGAAAATCT
Downstream sequence
TCTTTGTTCTGTTAGAGGTATGTCATAGAAGAAAGTTCTATAATTCAATGTTTGCTTGTCTTTTCAGCTGAGGAAGGTTGCTTATATTTTAGTAGCCAGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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