VISDB Viral Integration Site DataBase

VIS ID

TVIS10014131

Fusion event

HBV-DCC integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1759

Orient

-

Integrated sequence

GAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGG| |TTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCC

Chromosome

chr18

Cytoband

q21.2

Reference genome

Start

End

50723317/53196947 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-889-3p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-4696 ; hsa-mir-6500-3p ; hsa-mir-5092 ; hsa-mir-1255b-2-3p ; hsa-mir-6738-3p ; hsa-mir-3678-3p ; hsa-mir-544a ; hsa-mir-513b-5p ; hsa-mir-2467-3p ; hsa-mir-298 ; hsa-mir-17-3p ; hsa-mir-1205 ; hsa-mir-1184 ; hsa-mir-3158-5p ; hsa-mir-6847-5p ; hsa-mir-4719 ; hsa-mir-7853-5p ; hsa-mir-105-5p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-219a-2-3p

Nearest miRNA

hsa-mir-1-2/Upstream/3070384; hsa-mir-122/Downstream/40154;

Nearest TSS

Nearest CpG islands

None/Target, chr18-CpG: 67/Upstream/854595, chr18-CpG: 59/Downstream/1027452

Nearest cancer related gene

DCC(TSG, No orient, 0)

Upstream sequence

CTCCTGTGGTTTTGTAATAGAAATCTACCCTATAGTTTGTGCTTCTTCCTAGCCAAATTACTGTCTTATCTCCTAACTATGTACAGTTCAGTCAAGGAGA

Downstream sequence

GGTTTCATTATGTTAATAATTACATTGCCTGCAGGCTTTTTGATGTTGCATTCCCCATACAGAATAGAAACAGATTTCATAGAAATATCATTAAAGCTGT