Basic Information
VIS ID
TVIS10014136
Fusion event
HBV-LOC105373437 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1054
Orient
+
Integrated sequence
AACTTCCTATTAACAGGCCTATTGATTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATGTGGTTATCCTGCGTT| |GATGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTT
Host Sequence
Chromosome
chr2
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
13523504/13383379 (Hg38)
End
13523504/13383379 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105373437
Nearest miRNA
hsa-mir-3125/Upstream/645935; hsa-mir-10b/Downstream/5965050;
Nearest TSS
ENST00000437798/Upstream/665141; ENST00000434509/Downstream/154294;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/664486, chr2-CpG: 248/Downstream/1248874
Nearby gene
LOC100506474(-376366) ; LRATD1(+1249306) ;
Upstream sequence
atatacatcatggaataccatgcagcataaagtataatgtcccgtgcagcaacatggctggacctggaggccatagtcctaagcaaattaatacaggaac
Downstream sequence
aaaaagcaaaacaccacatattcccatgtatatgttggagctaaacattaagcacacatggacataaacatgggaacaatagatactgcacacgactagg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate