VISDB Viral Integration Site DataBase

VIS ID

TVIS10014143

Fusion event

HBV-ING5 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2160

Orient

+

Integrated sequence

TGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTC| |AGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGG

Chromosome

chr2

Cytoband

q37.3

Reference genome

Start

End

242633880/241694465 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-7157-3p ; hsa-mir-6737-3p ; hsa-mir-5008-3p ; hsa-mir-1914-5p ; hsa-mir-8485 ; hsa-mir-649 ; hsa-mir-6515-5p ; hsa-mir-4443 ; hsa-mir-6827-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-1225-3p ; hsa-mir-432-5p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-4650-5p ; hsa-mir-1972 ; hsa-mir-6769a-3p ; hsa-mir-331-3p ; hsa-mir-193a-5p

Nearest miRNA

hsa-mir-10b/Upstream/216483;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/7160, chr2-CpG: 167/Downstream/6963

Nearby gene

DTYMK(-7497) ; ING5(+7576) ;

Nearest cancer related gene

ING5(TSG, No orient, 0)

Upstream sequence

ctgggaggcagagcttgcagtgagccaagatcacaccactgcactccagcctgggcgacagagcgagactccatctcaaaaaaaaaagaaTCAGTaaaag

Downstream sequence

atataaaggagaaaaggacagaaccacaaataggcaacaaatatgttaaaaaaaagtttagcttcacttaaaatgaaataaatgtgattaaaatatttaa