Basic Information
VIS ID
TVIS10014146
Fusion event
HBV-LOC105369165 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1826
Orient
-
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA
Host Sequence
Chromosome
chr2
Cytoband
p16.2
Reference genome
GRCh37/hg19
Start
53012350/52785212 (Hg38)
End
53012350/52785212 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
LOC105369165
Nearest miRNA
hsa-mir-1301/Upstream/82597; hsa-mir-10b/Downstream/1063910;
Nearest TSS
ENST00000437798/Upstream/284460; ENST00000418451/Downstream/79023;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/155226, chr2-CpG: 28/Downstream/982542
Nearby gene
NRXN1(-1752676) ; ASB3(+884767) ;
Upstream sequence
atattgttgccaatatcagcactttattccattttattactgagtaatagttcattgtataaatatgtcattatttagttgtccattctTGTATGGGTAT
Downstream sequence
GTTTTTGGATATTCTCTGtgtattagtttaggttctccagagaaacagaaccaacagaatacaaatagatttattataagcaattatctcatgcagttat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate