Basic Information
VIS ID
TVIS10014148
Fusion event
HBV-chr20 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2211
Orient
-
Integrated sequence
CTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTT| |CACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATG
Host Sequence
Chromosome
chr20
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
10978248/10997600 (Hg38)
End
10978248/10997600 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA20B
Nearest miRNA
hsa-mir-103a-2/Upstream/347905; hsa-mir-1-1/Downstream/7473015;
Nearest TSS
ENST00000382410/Upstream/10925; ENST00000605338/Downstream/3704;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/322637, chr20-CpG: 37/Downstream/689274
Nearby gene
JAG1(-323554) ; LOC339593(+269059) ;
Upstream sequence
atggggtttcaccatgttggccaggatggtctcgatctcttgacctcgtgatccgccctcctcggcctcccaaagtgctgggattacaggcgtgagccgc
Downstream sequence
tgcacctggccagcatttttttaaatcacctcaagtgatatcagtttgcagcccaggttTAAGACTCCCTGAACTTAAGGCTATAGGGGAGATATGCAGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate