Basic Information
VIS ID
TVIS10014150
Fusion event
HBV-chr21 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1077
Orient
-
Integrated sequence
GATTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTC| |AATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTTGCCCGGCAACGGCCAGGTCTGTG
Host Sequence
Chromosome
chr21
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
44348586/42928476 (Hg38)
End
44348586/42928476 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7c/Upstream/1181635; hsa-mir-5692b/Downstream/22452;
Nearest TSS
ENST00000624081/Upstream/2830; ENST00000456957/Downstream/36887;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/34726, chr21-CpG: 200/Downstream/45498
Nearby gene
NDUFV3(-18813) ; PKNOX1(+46057) ;
Nearest cancer related gene
PKNOX1(TSG, +46057) ;
Upstream sequence
tgaaaccccgtctctactaaaaataaaaaaaattagccgggcgtggtggcgggtgcctgtagtcccagctacttgggaggctgaggcaggagaatgtatg
Downstream sequence
aacccggcaggcggagcttgcagtgagccgagattgcgccactgcactccagcatgggcgacagagcgagactccgtctcaaaaaaaaaaaaaaaagaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate