Basic Information
VIS ID
TVIS10014151
Fusion event
HBV-chr22 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
347
Orient
+
Integrated sequence
GTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTC| |TTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTT
Host Sequence
Chromosome
chr22
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
42552869/42156863 (Hg38)
End
42552869/42156863 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA22A
Nearest miRNA
hsa-mir-1281/Upstream/233566; hsa-let-7a-3/Downstream/3044091;
Nearest TSS
ENST00000624155/Upstream/16936; ENST00000332965/Downstream/53345;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/3666, chr22-CpG: 180/Downstream/112583
Nearby gene
CYP2D7(-12294) ; TCF20(+3150) ;
Upstream sequence
AAAAAGTGCACTGTGCCCTGGCAGGCCCTATGGACGTTGCCAAGTGAGATGGTGTGAAAATATGtcagcaagtggtagactaggaaactgcgggctctcg
Downstream sequence
ttctcttagagagctcaatgttaaagctataggagaccaaaacatcgtgagaattctagaaactagttaggatgctgcaatgccagctagtgcagagcca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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