Basic Information
VIS ID
TVIS10014152
Fusion event
HBV-chr22 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1413
Orient
-
Integrated sequence
GGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCG| |GGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCG
Host Sequence
Chromosome
chr22
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
42552876/42156870 (Hg38)
End
42552876/42156870 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA22A
Nearest miRNA
hsa-mir-1281/Upstream/233573; hsa-let-7a-3/Downstream/3044084;
Nearest TSS
ENST00000624155/Upstream/16943; ENST00000332965/Downstream/53338;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/3673, chr22-CpG: 180/Downstream/112576
Nearby gene
CYP2D7(-12301) ; TCF20(+3143) ;
Upstream sequence
GCACTGTGCCCTGGCAGGCCCTATGGACGTTGCCAAGTGAGATGGTGTGAAAATATGtcagcaagtggtagactaggaaactgcgggctctcgttctctt
Downstream sequence
agagagctcaatgttaaagctataggagaccaaaacatcgtgagaattctagaaactagttaggatgctgcaatgccagctagtgcagagccagggaggg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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