Basic Information
VIS ID
TVIS10014153
Fusion event
HBV-SPICE1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1591
Orient
+
Integrated sequence
CCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGC| |TTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGA
Host Sequence
Chromosome
chr3
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
113202856/113484009 (Hg38)
End
113202856/113484009 (Hg38)
Orient
-
Location type
Intronic
Target gene
SPICE1
miRNAs that regulate target gene
hsa-mir-27a-3p
Nearest miRNA
hsa-let-7g/Upstream/51809; hsa-mir-12124/Downstream/110867;
Nearest TSS
ENST00000440867/Upstream/42399; ENST00000483946/Downstream/4981;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/42215, chr3-CpG: 38/Downstream/30807
Upstream sequence
aagtaaagctctcctcagcaaatgtaaaagaacagaaattataacaaactatctctcagaccacagtgcaatcaaactagaactcaggattgagaatctc
Downstream sequence
actttttttggttggtaggctattaattactgcctcaatttcagaacttgttattggtctattcagggattcgacttcttctggtttagacttgggaggg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate