Basic Information
VIS ID
TVIS10014160
Fusion event
HBV-EHHADH-AS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
896
Orient
+
Integrated sequence
CGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACAAAGAGATGGGGTTACTCTCTAAATTTTATGGGTTATGTCATTGGA| |TGTTATGGGTCCTTGCCACAAGAACACATCATACAAAAAATCAAAGAATGTTTTAGAAAACTTCCTATTAACAGGCCTATTGATTGGAAAGTATGTCAAC
Host Sequence
Chromosome
chr3
Cytoband
q27.2
Reference genome
GRCh37/hg19
Start
184906578/185188790 (Hg38)
End
184906578/185188790 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA3C
Target gene
EHHADH-AS1
Nearest miRNA
hsa-let-7g/Upstream/947301; hsa-mir-1248/Downstream/64420;
Nearest TSS
ENST00000440867/Upstream/25889; ENST00000438798/Downstream/46672;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/35096, chr3-CpG: 43/Downstream/65063
Upstream sequence
cactgctttgaatgcatcccagagattctggtatgtcgtgtctttgttcttgttggtttcaaagaacatctttatttctgccttcatttcgttatgtacc
Downstream sequence
ATGGCTACCAAAAAGGTTCAGATAATCTAGTGAGGCTGCAATATTTCTGATTTCTAGGTATCTGTTTTAAAGACAAATCTAAGACCTTGAAATTTTAGGT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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