Basic Information
VIS ID
TVIS10014172
Fusion event
HBV-LOC101928306 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2769
Orient
+
Integrated sequence
AATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGC| |GGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCAC
Host Sequence
Chromosome
chr4
Cytoband
p16.2
Reference genome
GRCh37/hg19
Start
4925643/4923916 (Hg38)
End
4925643/4923916 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC101928306
Nearest miRNA
hsa-mir-4800/Upstream/2673760; hsa-mir-12113/Downstream/999359;
Nearest TSS
ENST00000502981/Upstream/61488; ENST00000513705/Downstream/95521;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/51470, chr4-CpG: 27/Downstream/95360
Nearby gene
MSX1(-59983) ; CYTL1(+90671) ;
Upstream sequence
ttatagatgactatttacaaaactgaaaacaggatttagaaaaaccaaaatgggaggtacaatattccagagctagtaacaggaagctgtttgcaggact
Downstream sequence
ccatatggaactgtgagtcaattaaacctctttcctttataaattatccagtctcgagcagttctttatagcagtgtgaaaacagactactacaccccca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate