Basic Information
VIS ID
TVIS10014184
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2939
Orient
-
Integrated sequence
GATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCA| |GATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTT
Host Sequence
Chromosome
chr6
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
125849595/125528449 (Hg38)
End
125849595/125528449 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/5513192; hsa-mir-1202/Downstream/956182;
Nearest TSS
ENST00000381078/Upstream/83266; ENST00000423208/Downstream/145904;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/164730, chr6-CpG: 232/Downstream/219127
Nearby gene
HDDC2(-226313) ; LINC02523(+145904) ;
Upstream sequence
GAAATAGATGAAAGGAATAACGGTGATGAGACCAGACAAGATGCCCAGCTCATAAGTCGCCCCAGCAGTGTCAGAATGAGAGGAGCTACTGGTAACTAGA
Downstream sequence
tacatgtattatttaccattgcatcccctactgtgtccaacacagtgccctgaatttactgggtacagaacaaatgtttgatgaatgaatgaatGCATTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate