Basic Information
VIS ID
TVIS10014188
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
505
Orient
+
Integrated sequence
CTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCA| |GCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTAT
Host Sequence
Chromosome
chr6
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
21445105/21444874 (Hg38)
End
21445105/21444874 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-3691/Upstream/2872994; hsa-mir-10398/Downstream/5702752;
Nearest TSS
ENST00000381078/Upstream/89578; ENST00000244745/Downstream/67021;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1041322, chr6-CpG: 131/Downstream/142316
Nearby gene
CDKAL1(-212471) ; SOX4(+148867) ;
Nearest cancer related gene
SOX4(OG, +148867) ;
Upstream sequence
tattctgtacttaactttcaaaatattatttttcttttgcaataaattgcatctcctttgctgtgtgtctctgtttttttatttcttctaCAAAAACAAA
Downstream sequence
AACTTGGGGAAATAGTGACGCTTCCTGGCCTAGATTTATCACCATCTGGGAAGCAGAATGAGATGCTTGGCGCTGCCACTGCCACTTTCATCTGCCACAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate