Basic Information
VIS ID
TVIS10014190
Fusion event
HBV-LOC101927870 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1591
Orient
+
Integrated sequence
CCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGC| |TTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGA
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
103099831/103459384 (Hg38)
End
103099831/103459384 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
LOC101927870
Nearest miRNA
hsa-mir-10525/Upstream/987853; hsa-mir-10399/Downstream/11193961;
Nearest TSS
ENST00000635602/Upstream/13207; ENST00000401970/Downstream/23564;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/12991, chr7-CpG: 122/Downstream/529694
Nearby gene
SLC26A5(-13207) ; RELN(+12400) ;
Upstream sequence
GCATTTTAAAACTTGTTCTGAGGATGATTCTGTCTTTGTCAAGATGACAGACCTATACTGTATAAAATTTAGACCGCTTAGTTATCGTATTTTTCTGCCA
Downstream sequence
actttttttggttggtaggctattaattactgcctcaatttcagaacttgttattggtctattcagggattcgacttcttcctggtttagtcttgggagg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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