Basic Information
VIS ID
TVIS10014192
Fusion event
HBV-LRRC72 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
449
Orient
-
Integrated sequence
GTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCT| |GGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACC
Host Sequence
Chromosome
chr7
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
16621086/16581461 (Hg38)
End
16621086/16581461 (Hg38)
Orient
+
Location type
Exonic
Target gene
LRRC72
Nearest miRNA
hsa-mir-339/Upstream/9514416; hsa-mir-10399/Downstream/1545759;
Nearest TSS
ENST00000635602/Upstream/50881; ENST00000430000/Downstream/12763;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/54412, chr7-CpG: 31/Downstream/5062
Upstream sequence
ATAGAAATAGTAAAGAATGGGAAGCATGGTTAGCATATTATAACATAAATGCTGAAGTCACTGAAAATGTACCAGAAGACAGATGGACAGGAAAATTGAC
Downstream sequence
TCAAATGCTCACAGTTACACTGAGATAAGCCCTGGTATTTCTAGATATCTTAGTGGTTTTCAGTTGTATATTAAACTTCCCTGTGACTTAGCATATTACA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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