Basic Information
VIS ID
TVIS10014199
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2211
Orient
-
Integrated sequence
CTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTT| |CACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATG
Host Sequence
Chromosome
chr8
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
42030012/42172494 (Hg38)
End
42030012/42172494 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/511986; hsa-mir-10400/Downstream/723703;
Nearest TSS
ENST00000518652/Upstream/4729; ENST00000518983/Downstream/8270;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/18914, chr8-CpG: 50/Downstream/98677
Nearby gene
AP3M2(-1311) ; PLAT(+2224) ;
Upstream sequence
GCAGTGGCTAAAGAAGGCAAGACAGTGACCCAGCTATGCTCTCCCGCAGTCAGAGGCAAGGAGCTCACGAGGCTGGAGTCCCAACTGGACCAAGAAGCGT
Downstream sequence
cgcctggccCTGTTAAAATTTTTAAAAGGAAATTTgaccagcctggccaacatggcaaaacccatctctactgaaaaatataaaaattagctgggcctgg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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