Basic Information
VIS ID
TVIS10014201
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2852
Orient
+
Integrated sequence
CACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATG| |GGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCA
Host Sequence
Chromosome
chr9
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
106440110/103677828 (Hg38)
End
106440110/103677828 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7a-1/Upstream/5448611; hsa-mir-12126/Downstream/2923100;
Nearest TSS
ENST00000422679/Upstream/247936; ENST00000647310/Downstream/321927;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/1939034, chr9-CpG: 38/Downstream/321521
Nearby gene
CYLC2(-659340) ; SMC2(+416431) ;
Upstream sequence
cgtggtggctcacgcctgtaatcccagcactttgggaggctgaggtaggtggattacctgaggtcaggagttcgagaccagcctgaccaacatggtgaaa
Downstream sequence
AGCTTTCTGGCTCTTCCCCAAGTTACAGAAGTCCTGCTGCAACATATTCACTGTAAATATCAAGGTGCCTATGCGTTTTCTCAATTATCATGCCTGACTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate